Anti-Sclerostin [AbD09097]

Absolute Antibody

Anti-Sclerostin [AbD09097]

9

This antibody binds mouse sclerostin and cross reacts with human sclerostin and recognizes an epitope adjacent to sclerostins binding site for the Wnt co-receptor LRP6. Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) doma

The binding reactivity of this antibody for mouse sclerostin was tested using ELISA. This antibody binds mouse and human sclerostin with a binding affinity of Kd= 46nM and Kd=260 nM respectively. This antibody efficiently neutralizes sclerostins Wnt inhibitory activity. In vitro interaction analysis using sclerostin variants revealed that this neutralizing Fab binds to sclerostins flexible second loop, which has been shown to harbor the LRP5/6 binding motif (PMID: 27558933).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

AbD09097

SOST

sclerostin

CDD; DAND6; sclerostin; SOST1; VBCH

Human

IgG1

Sclerostin

This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human Fab format, created for improved compatibility with existing reagents, assays and techniques.

Human, Mouse

-20°C,2°C to 8°C

12352203