Anti-SIRP g [OX-119]

Absolute Antibody

Anti-SIRP g [OX-119]

7

Hybridoma supernatants were initially screened by ELISA, using SIRPg-CD4, human SIRPa-Fc, human SIRPb-Fc or CD4 to eliminate hybridomas with cross-reactivity to rat CD4, human SIRPa, and SIRPb. There is some marginal binding of OX-119 to SIRPb transfected

OX-119 is able to perform staining of peripheral blood myeloid cells (PBMCs) and block SIRPg-mediated apoptosis. OX-119 can also be used in IP, FC and ELISA.

Flow Cytometry, ImmunoPrecipitation, ELISA, Neutralisation/Blocking

IP; FC; ELISA; block

Research Use Only

Monoclonal

OX-119

SIRPG

signal regulatory protein gamma

bA77C3.1; CD172 antigen-like family member B; CD172g; CD172g antigen; signal-regulatory protein beta-2; signal-regulatory protein gamma; SIRP beta 2; SIRPB2; SIRP-B2; SIRPgamma; SIRP-gamma

Human

IgG1

Signal-regulatory protein gamma

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

OX-119 was prepared by immunizing BALB/c mice with a chimeric protein made up of human SIRPg and a leader peptide of rat CD4 domain (SIRPg-CD4 ).

-20°C,2°C to 8°C

12352203