anti-SIT antibody [SIT-01] (PE)

Arigo Biolaboratories

anti-SIT antibody [SIT-01] (PE)

23

Flow Cytometry

Research Use Only

Monoclonal

SIT-01

0.1 mg/ml

RPE

SIT1

signaling threshold regulating transmembrane adaptor 1

gp30/40; SHP2 interacting transmembrane adaptor; SHP-2 interacting transmembrane adaptor protein; SHP2-interacting transmembrane adapter protein; SHP2-interacting transmembrane adaptor protein; signaling threshold-regulating transmembrane adapter 1; SIT; SIT-R; suppression inducing transmembrane adaptor 1; suppression-inducing transmembrane adapter 1

Mouse

IgG1

SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.

Human

2°C to 8°C

12352203