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anti-SLC12A3 / NCC antibody

ARG22199
Arigo Biolaboratories
ApplicationsElectron Microscopy, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityRat
TargetSlc12a3
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-SLC12A3 / NCC antibody
  • Delivery Days Customer
    23
  • Applications
    Electron Microscopy, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID54300
  • Target name
    Slc12a3
  • Target description
    solute carrier family 12 member 3
  • Target synonyms
    Na-Cl symporter; NCC; solute carrier family 12 (sodium/chloride transporter), member 3; solute carrier family 12 (sodium/chloride transporters), member 3; solute carrier family 12 member 3; thiazide-sensitive Na-Cl cotransporter; thiazide-sensitive sodium-chloride cotransporter; TSC
  • Host
    Rabbit
  • Scientific Description
    This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartters syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Reactivity
    Rat
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203