Anti-Smad7

Applied Biological Materials

Anti-Smad7

9

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Rabbit

IgG

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Human, Mouse, Rat

-20°C,2°C to 8°C

12352203