anti-SOS1 antibody [SOS-01]

Arigo Biolaboratories

anti-SOS1 antibody [SOS-01]

23

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

SOS-01

1 mg/ml

Unconjugated

>95%

SOS1

SOS Ras/Rac guanine nucleotide exchange factor 1

GF1; GGF1; GINGF; gingival fibromatosis, hereditary, 1; guanine nucleotide exchange factor; HGF; NS4; son of sevenless homolog 1; SOS-1

Mouse

IgG1

The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization; the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.

Human

-20°C

12352203