Bio-Connect

Anti-spike protein [PZZ 21]

AB03630-30.11-BT
Absolute Antibody
ApplicationsImmunoFluorescence, ELISA, Neutralisation/Blocking, Other Application
Product group Antibodies
ReactivityVirus
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Overview

  • Supplier
    Absolute Antibody
  • Product Name
    Anti-spike protein [PZZ 21]
  • Delivery Days Customer
    9
  • Antibody Specificity
    The antibody binds the S1 region of the spike protein of PEDV. The S protein is a type I glycoprotein that plays a crucial role in virus attachment, entry, receptor binding, cell membrane fusion and induction of neutralizing antibodies. The S protein can
  • Application Supplier Note
    The specificity of the original format of the antibody was confirmed by ELISA analysis. Immunofluorescence assay revealed that the scFv stained PEDV-infected Vero E6 cells but did not react with uninfected control cells. The scFv was shown to inhibit PEDV infectivity by the plaque reduction neutralization assay (the virus neutralization titer was 6.25 microg/mL). Results showed the a cocktail of the scF fragment, PZZ 24 and PZZ 35 neutralized viral infection at 3.125 microg/mL. Finally, piglets orally administered with a mixture of scFv fragment, PZZ 24 and PZZ 35 showed no to mild clinical symptoms, significantly less viral shedding, no mortality and no intestinal lesions.
  • Applications
    ImmunoFluorescence, ELISA, Neutralisation/Blocking, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    PZZ 21
  • Reactivity
    Virus
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203