Anti-Spike protein (RBD) [Sb#68]

Absolute Antibody

Anti-Spike protein (RBD) [Sb#68]

9

This antibody recognizes and binds the SARS CoV 2 C-terminal receptor binding domain (RBD) located in the extracellular portion of the spike protein.

This antibody is recommended for detection of SARS CoV 2 or 2019-nCoV. Sb#68 is a strong binder and binds the 2019-nCoV ectodomain with an affinity of KD ~ 37 nM (Walter et al., 2020). The initial characterization and binding activity of this antibody to SARS CoV2 spike protein was confirmed with ELISA (Walter et al., 2020). This antibody is a mild inhibitor for interaction between hACE2 and RBD of SARS CoV2. This clone binds to a non-overlapping epitope relative to S#15 (Ab02013) what can be used in develoepment of anti-Covid-19 therapuetics granting together increased avidity to the spike protein (Walter et al., 2020).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

Sb#68

S

surface glycoprotein

GU280_gp02; spike glycoprotein; surface glycoprotein

Human

IgA

Spike glycoprotein

This chimeric human antibody was made using the variable domain sequences of the original VHH format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203