Anti-Spike protein (RBD) [Sb#68]

Absolute Antibody

Anti-Spike protein (RBD) [Sb#68]

9

This antibody recognizes and binds the SARS CoV 2 C-terminal receptor binding domain (RBD) located in the extracellular portion of the spike protein.

This antibody is recommended for detection of SARS CoV 2 or 2019-nCoV. Sb#68 is a strong binder and binds the 2019-nCoV ectodomain with an affinity of KD ~ 37 nM (Walter et al., 2020). The initial characterization and binding activity of this antibody to SARS CoV2 spike protein was confirmed with ELISA (Walter et al., 2020). This antibody is a mild inhibitor for interaction between hACE2 and RBD of SARS CoV2. This clone binds to a non-overlapping epitope relative to S#15 (Ab02013) what can be used in develoepment of anti-Covid-19 therapuetics granting together increased avidity to the spike protein (Walter et al., 2020).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

Sb#68

S

surface glycoprotein

GU280_gp02; spike glycoprotein; surface glycoprotein

Camel

Spike glycoprotein

Virus

-20°C,2°C to 8°C

12352203