Anti-ssDNA/dsDNA [m3D8]

Absolute Antibody

Anti-ssDNA/dsDNA [m3D8]

7

This catalytic antibody binds to DNA oligomers both single- and double-stranded, irrespective of the sequence, showing DNA-hydrolytic activity. DNA is the principle storage of genetic information and usually sequestered within the nucleus in Eukaryotes. Extracellular DNA is a key danger signal for the immune system and an antigen to disease-causing auto-antibodies (incl. DNA-hydrolysing antibodies) e.g. in Systemic Lupus Erythematosus. Antibody formats comprising different numbers of variable domains may be useful tools in investigating the significance of these catalytic antibodies in disease.

ELISA, Other Application

Research Use Only

-20°C,2°C to 8°C

12352203