Anti-ssRNA (sequence specific) [BRG (5E08)]

Absolute Antibody

Anti-ssRNA (sequence specific) [BRG (5E08)]

9

This antibody binds to an RNA fragment of a minimal 10 nt sequence N3U4G5C6A7N8A9G10G11N12.

It was demonstrated that the binding of BRP Fab fragment to the RNA molecule stabilised an RNA hairpin structure which was not steady in the absence of the Fab (Shao et al., 2016). Consequently, BRP might be used to capture dynamic RNAs in distinct conformational states and allow structural analysis of nucleic acids. Additionally, BRG Fab antibody fragment was shown to inhibit Dbr1 debranching of the RNA target (Shao et al., 2016).

Functional Assay

Research Use Only

Monoclonal

BRG (5E08)

Rat

IgG2b

This chimeric rat antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.

Other Species

-20°C,2°C to 8°C

12352203