Anti-ST2L [STLM62 (C2494)], Human IgG1, Fc Silent(tm), kappa

Absolute Antibody

Anti-ST2L [STLM62 (C2494)], Human IgG1, Fc Silent(tm), kappa

9

This antibody specifically binds an epitope in domain I of the human ST2L and cross reacts with cynomolgus monkey ST2L. ST2L a transmembrane receptor that belongs to the IL-1 receptor family which is expressed on the cell surface of a wide variety of immu

This antibody binds human ST2L and blocks the interaction between IL-33 and ST2L. This antibody was capable of recognizing recombinant human ST2L extracellular domain (ST2L-ECD) using an ELISA assay (PMID: 27294560). The original human IgG2 chimeric version of the antibody binds human and cynomolgus monkey ST2L with a binding affinity of 28 pM and 12 pM respectively (US9090694). This antibody was capable of binding ST2L expressed by LAD2 mast cells in a flow cytometric assay. This antibody was reported to block the IL-33 induced activation of NF-kB in a dose dependent manner. This antibody also blocked IL-1RAcP from binding to the ST2L/IL-33 complex. It can also inhibit cytokine secretion by human basophilic cell line KU812 (PMID: 27294560).

Functional Assay, Flow Cytometry, ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

STLM62 (C2494)

IL1RL1

interleukin 1 receptor like 1

DER4; FIT-1; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL33R; interleukin 1 receptor-related protein; interleukin-1 receptor-like 1; ST2; ST2L; ST2V; T1

Human

IgG1

Interleukin-1 receptor-like 1

This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG2b format, created for improved compatibility with existing reagents, assays and techniques.

Human, Monkey

-20°C,2°C to 8°C

12352203