Anti-Stat2 (Ab-690)

Applied Biological Materials

Anti-Stat2 (Ab-690)

9

Stat2 (Ab-690) Antibody detects endogenous levels of total Stat2 protein.

Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

Rabbit

IgG

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Human

-20°C,2°C to 8°C

12352203