Anti-Structural polyprotein [CHK152], Mouse Fab fragment, His-Tagged, kappa

Absolute Antibody

Anti-Structural polyprotein [CHK152], Mouse Fab fragment, His-Tagged, kappa

9

This antibody is specific for the wings of the A domain on E2 of CHIKV.

The structure of the original version of this antibody was determined using cryo-EM. Further the original version of this antibody was used for a neutralization assay on CHIKV and Vero cells (Sun et al., 2013; PMID:23577234) (Pal et al., 2013; PMID:23637602) (Pal et al., 2014; PMID:24829346). The original version of this antibody was used for a prophylaxis study on immunodeficient Ifnar-/- C57BL/6 mice, which were infected with CHIKV (Pal et al., 2013; PMID:23637602) (Pal et al., 2014; PMID:24829346). This antibody was used for an ELISA on different CHIKV virions (Pal et al., 2013; PMID:23637602). The ability of this antibody to reduce viral infection in rhesus macaques was assessed. It showed that it was indeed able to reduce the viral load in these animals (Pal et al., 2014; PMID:24829346). This antibody has shown its ability to block access to CHKV virions and to block the E2 surface glycoprotein from enzymatic cleavage by trypsin (Blijleven et al., 2022; PMID:35215863).

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

CHK152

CHIKVgp2

structural polyprotein

CHIKVgp2; structural polyprotein

Mouse

Structural polyprotein

Virus

-20°C,2°C to 8°C

12352203