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ProductsBack/Anti-Succinyl-Histone H3 (Lys79) Rabbit pAb

Anti-Succinyl-Histone H3 (Lys79) Rabbit pAb

PTM-412
PTM BIO
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Mouse, Rat
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Overview

  • Supplier
    PTM BIO
  • Product Name
    Anti-Succinyl-Histone H3 (Lys79) Rabbit pAb
  • Delivery Days Customer
    5
  • Antibody Specificity
    Anti-Succinyl-Histone H3 (Lys79) Rabbit pAb detects histone H3 only when it is succinylated at Lys79.
  • Applications
    Western Blot
  • Applications Supplier
    WB
  • Category Supplier
    Antibody
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP68431
  • Protein Name
    Histone H3.1
  • Scientific Description
    Succinylation is a post-translational modification where a succinyl group (-CO-CH2-CH2-COOH) is added to a lysine residue in proteins, including histones. This addition of succinyl group changes lysine's charge from +1 to -1 (at physiological pH) and introduces a relatively large structural moiety (100 Da), bigger than acetylation (42 Da) or methylation (14 Da). It is expected to lead to more significant changes in protein structure and function. Lysine succinylation, particularly at Lys79 on histone H3, is mediated by the enzyme KAT2A and has implications in tumor growth and disease progression. KAT2A-mediated succinylation is also observed in hepatitis B virus (HBV) infection, impacting HBV replication and epigenetic regulation.
  • Shelf life instruction
    Stable for 12 months from date of receipt/reconstitution.
  • Reactivity
    Human, Mouse, Rat
  • Reactivity Supplier
    Human, Mouse, Rat
  • Reactivity Supplier Note
    Protein A and immunogen affinity purified
  • Storage Instruction
    Store at -20°C. Avoid freeze/thaw cycles.
  • UNSPSC
    12352203

References

  • Yu Bo, et al. 'KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling' Nature Communications (2022)
    Read more
  • Yu Hai-Bo, et al. 'SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome' CLINICAL SCIENCE (2021)
    Read more
  • Qin Yi-Ping, et al. 'KAT2A Promotes Hepatitis B Virus Transcription and Replication Through Epigenetic Regulation of cccDNA Minichromosome' Frontiers in Microbiology (2022)
    Read more
  • Can Cao, et al. 'GCN5 participates in KLF4-VEGFA feedback to promote endometrial angiogenesis' iScience (2022)
    Read more