Immunohistochemical staining of formalin-fixed and paraffin-embedded human pancreas tissue sections using anti-SV2A Rabbit Monoclonal Antibody (Clne RM520) at 1:100 dilution, for 1hr at room temperature.
Immunohistochemical staining of formalin-fixed and paraffin-embedded human pancreas tissue sections using anti-SV2A Rabbit Monoclonal Antibody (Clne RM520) at 1:100 dilution, for 1hr at room temperature.
anti-SV2A, Rabbit Monoclonal (RM520)
REV-31-1412-00
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetSV2A
Overview
- SupplierRevMAb Biosciences
- Product Nameanti-SV2A, Rabbit Monoclonal (RM520)
- Delivery Days Customer10
- Antibody SpecificityThis antibody reacts to human, mouse and rat SV2A (Synaptic vesicle glycoprotein 2A).
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDRM520
- Gene ID9900
- Target nameSV2A
- Target descriptionsynaptic vesicle glycoprotein 2A
- Target synonymsSV2; synaptic vesicle glycoprotein 2A
- HostRabbit
- IsotypeIgG
- Protein IDQ7L0J3
- Protein NameSynaptic vesicle glycoprotein 2A
- Scientific DescriptionRecombinant Antibody. This antibody reacts to human, mouse and rat SV2A (Synaptic vesicle glycoprotein 2A). Isotype: Rabbit IgG. Immunogen: A peptide corresponding to the N-terminus of human SV2A. Applications: IHC, WB. SV2A (Synaptic Vesicle protein 2A) is an integral membrane glycoprotein present in synaptic vesicles. SV2s have 12 transmembrane domains predicted by sequence analysis. There are three characterized isoforms, SV2A, SV2B and SV2C. SV2A is expressed ubiquitously throughout the brain. SV2B has a more restricted distribution with varying degrees of coexpression with SV2A. SV2C is more closely related to SV2A but shows a very restricted expression pattern. The highest expression levels were observed in phylogenetically old brain areas like pallidum, the midbrain and the olfactory bulb. SV2A is probably involved in the maintenance of a pool of synaptic vesicles competent for calcium-stimulated exocytosis. SV2A is a highly glycosylated synaptic vesicle protein with homology to transmembrane transporters. This protein plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. - SV2A (Synaptic Vesicle protein 2A) is an integral membrane glycoprotein present in synaptic vesicles. SV2s have 12 transmembrane domains predicted by sequence analysis. There are three characterized isoforms, SV2A, SV2B and SV2C. SV2A is expressed ubiquitously throughout the brain. SV2B has a more restricted distribution with varying degrees of coexpression with SV2A. SV2C is more closely related to SV2A but shows a very restricted expression pattern. The highest expression levels were observed in phylogenetically old brain areas like pallidum, the midbrain and the olfactory bulb. SV2A is probably involved in the maintenance of a pool of synaptic vesicles competent for calcium-stimulated exocytosis. SV2A is a highly glycosylated synaptic vesicle protein with homology to transmembrane transporters. This protein plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203