anti-Synaptojanin 1 antibody [5H1]

Arigo Biolaboratories

anti-Synaptojanin 1 antibody [5H1]

23

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

5H1

Unconjugated

Synj1

synaptojanin 1

synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1; synaptojanin-1

Mouse

IgG1

Synaptojanin is a phosphatidylinositol phosphatase involved in clathrinmediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms; one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Downs syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4,5- bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008).

Rat

-20°C

12352203