anti-Tau phospho (Ser416) antibody

Arigo Biolaboratories

anti-Tau phospho (Ser416) antibody

23

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Mapt

microtubule-associated protein tau

microtubule-associated protein tau; Mtapt; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; pTau; RNPTAU; Tau; Tau microtubule-associated protein

Rabbit

IgG

Phosphorylated

Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimers disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimers disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3).

Rat

-20°C

12352203