Anti-TCR [Desire-1]

Absolute Antibody

Anti-TCR [Desire-1]

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mAb desire-1 recognises an epitope contributed by both the alpha and beta chains of the KB5-C20 TCR.

Desire-1 has been used for the immunoprecipitation of soluble TCR molecules (Gregoire 1991 & Hua 1986). An FITC conjugated desire-1 has been used in flow cytometric analysis as a marker for clonotype expression (Schonrich 1991). Further, a Fab fragment derived from desire-1 has been used in the crystallisation of the T-cell receptor for 3D structure determination (Housset 1997).

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Other Application

IP; FC; IF; crystallisation

Research Use Only

Monoclonal

Desire-1

Mouse

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

Mouse

Mouse

mAb desire-1 was obtained after fusion of spleen cells from a BALB.K mouse immunised twice with KB5-C20 clone cells in RPMI 1640 medium, with non-Ig-producing myeloma cells X63-Ag8.653. Desire-1 was selected for its capacity to inhibit selectively the H-2Kb-specific cytolysis by clone KB5-C20.

-20°C,2°C to 8°C

12352203