anti-TEM8 / Anthrax Toxin Receptor 1 antibody

Arigo Biolaboratories

anti-TEM8 / Anthrax Toxin Receptor 1 antibody

23

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Polyclonal

Unconjugated

ANTXR1

ANTXR cell adhesion molecule 1

2310008J16Rik; 2810405N18Rik; anthrax toxin receptor 1; ATR; GAPO; TEM8; tumor endothelial marker 8

Rabbit

IgG

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]

Human

-20°C

12352203