Anti-TGF beta [1D11.16.8]

Absolute Antibody

Anti-TGF beta [1D11.16.8]

9

This antibody recognizes and binds human, mouse, rat, cow, dog, hamster, monkey and other non-human primate transforming growth factor (TGF) beta 1, 2 and 3. TGF beta is a multifunctional cytokine that exists as five isoforms (TGF beta 1-5) that share 70-

This antibody was able to neutralize the biological activity of both TGF-beta 1 and beta 2 in vitro. This antibody could detect the dimeric form of TGF-beta 2 in western blots. This antibody was also reported to immunoprecipitate [125I]-TGF-beta 2 (PMID: 2537357). This antibody is also able to neutralize the growth promoting actions of TGF-B1 and B2 in the NRK proliferation assay and TGF-B induced alkaline phosphatase production in an assay using the ROS 17.2.8 osteosarcoma cell line (US5571714). This antibody was used for detection of TGF-beta production in vivo in spleens sections of L. donovani-infected hamsters using immunohistochemistry (PMID: 9488418). This antibody was also used for the immunohistochemical analysis of FFPE human renal biopsy specimens for presence of TGF-beta (PMID: 10515378).

Functional Assay, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking

Research Use Only

Monoclonal

1D11.16.8

TGFB1

transforming growth factor beta 1

TGF-beta-1; transforming growth factor beta-1; transforming growth factor beta-1 proprotein; transforming growth factor, beta 1 (Camurati-Engelmann disease)

Human

IgG1

TGFB3 protein

This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.

Bovine, Canine, Hamster, Human, Monkey, Mouse, Rat

-20°C,2°C to 8°C

12352203