Anti-Thyroid peroxidase [WR1.7]

Absolute Antibody

Anti-Thyroid peroxidase [WR1.7]

9

TPO is a cell surface enzyme responsible for thyroid hormone synthesis and present in virtually all patients with active autoimmune thyroid disease.

WR.1.7. binds human TPO with a Kd of 2.9 x 10^-10 M (Chazenbalk et al, 1993). Competition assays were used to characterise the WR1.7 eptitope with respect to other clones, identifying that WR1.7 binds a distinct eptitope to clone TR1.9 (Chazenbalk et al, 1993). WR1.7, TR1.9, SP1.4, and TR1.8 together map the immunodominant region of TPO recognised by autoantibodies in patients sera (Nishikawa et al, 1994). WR1.7 was able to inhibit TPO autoantibodies in patients sera as shown with further competition studies between antibody fragments and serum TPO autoantibodies (Chazenbalk et al, 1993). WR1.7 has been used to detect cells expressing cell surface TPO through flow cytometry (Jaume et al, 1999).

Flow Cytometry, Other Application, RadioImmunoAssay

Research Use Only

Monoclonal

WR1.7

TPO

thyroid peroxidase

MSA; TDH2A; thyroid microsomal antigen; thyroid peroxidase; thyroperoxidase; TPX

Rabbit

IgG

Thyroid peroxidase

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203