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Anti-TIGIT [4D4]

Name: Anti-TIGIT [4D4]
SKU: Ab00973-2.0_A16
Availability: BackOrder

Ab00973-2.0

ApplicationsFlow Cytometry, Other Application

Product group Antibodies

Overview

Supplier
Absolute Antibody
Product Name
Anti-TIGIT [4D4]
Delivery Days Customer
7
Application Supplier Note
4D4 is an agonistic anti-TIGIT antibody, and addition of plate bound 4D4 to anti-CD3/anti-CD28 stimulated T cells was shown to inhibit their proliferation (Joller 2011). Further, 4D4 has been used in order to identify genes that are downstream of TIGIT signaling in Tregs, as TIGIT engagement might modulate the Treg phenotype in tumor tissue (Liu 2016).
Applications
Flow Cytometry, Other Application
Applications Supplier
Agonist; Fc
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
4D4
Host
Mouse
Isotype
IgG2a
Protein IDP86176
Protein Name
T-cell immunoreceptor with Ig and ITIM domains
Scientific Description
This chimeric mouse antibody was made using the variable domain sequences of the original Hamster format, for improved compatibility with existing reagents, assays and techniques.
Reactivity Supplier
Mouse
Reactivity Supplier Note
Armenian hamsters were immunized with recombinant mouse TIGIT tetramers by a combination of s.c. and food pad immunization and booster injections. Draining lymph nodes were fused with Sp2/0-Ag14 cells, selected in HAT (hypoxanthine/aminopterin/thymidine) medium and supernatants were screened for specificity by ELISA and flow cytometry using TIGIT-transfectants.
Storage Instruction
-20°C,2°C to 8°C
UNSPSC
12352203