anti-TIRAP / Mal antibody

Arigo Biolaboratories

anti-TIRAP / Mal antibody

23

Western Blot

Research Use Only

Polyclonal

0.5 mg/ml

Unconjugated

TIRAP

TIR domain containing adaptor protein

adapter protein wyatt; adaptor protein Wyatt; BACTS1; Mal; MyD88 adapter-like protein; MyD88-2; toll/interleukin-1 receptor domain-containing adapter protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Toll-like receptor adaptor protein; wyatt

Goat

IgG

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Human

-20°C

12352203