Anti-Tissue factor [5G9]

Absolute Antibody

Anti-Tissue factor [5G9]

7

The antibody binds specifically to TF, a hemostatic protein which is involved in the extrinsic pathway of coagulation. TF is receptor for circulating serine protease factor VIIa, activating the catalytic VIIa protease domain. The complex formed functions to activate the zymogen factor X into activated factor Xa, which then catalyses the formation of Prothrombin to Thrombin. The pathways results in a fibrin clot which acts to stop bleeding. The monoclonal antibody 5G9 acts as a competitive inhibitor of factor X, thereby inhibiting its activation by the TF.VIIa complex and the formation of a clot.

Western Blot, ELISA, Neutralisation/Blocking

ELISA; WB; Block

Research Use Only

Tissue factor

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203