Anti-Tissue factor [hTFFab148H]

Absolute Antibody

Anti-Tissue factor [hTFFab148H]

9

This antibody binds human tissue factor (TF) a hemostatic protein which is involved in the extrinsic pathway of coagulation. TF is receptor for circulating serine protease factor VIIa, activating the catalytic VIIa protease domain. The complex formed func

The binding characterization of this Fab antibody was done using ELISA and dot blot. This antibody shows positive plasma coagulation inhibitory activity. This antibody is capable of neutralizing human tissue factor in vitro by inhibiting the binding of TF factor/Vlla complex to factor X. The inhibition rate increase with the concentration. The pharmacodynamic and pharmacokinetic activity of this antibody was studied in vivo in rat models (CN101423552).

Western Blot, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

hTFFab148H

F3

coagulation factor III, tissue factor

CD142; coagulation factor III (thromboplastin, tissue factor); TF; TFA; tissue factor

Mouse

IgG1

Tissue factor

This chimeric mouse antibody was made using the variable domain sequences of the original Human Fab format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203