Anti-TL1A [TAN2-2]

Absolute Antibody

Anti-TL1A [TAN2-2]

9

This antibody is specific for TL1A, a member of the TNF ligand family. TL1A is expressed by endothelial cells, tissue macrophages, monocyte-derived dendritic cells, plasma cells and lamina propria-derived lymphocytes. Among peripheral blood cells, TL1A ha

This antibody has been used in FACS analyses to reveal the role of TL1A in humoral immune responses and its mechanism of action in the development of collagen-induced arthritis (Wang et al, 2013), and in immunofluorescence confocal microscopy to demonstrate how chronic DR3 signaling could promote pathogenesis in inflammatory bowel disease (Taraban et al, 2011). The therapeutic potential of this antagonistic anti-TL1A antibody in countering the DR3-TL1A pathway in the inflammatory joint disease has been confirmed in both of the murine adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) models (Bull et al, 2008). In addition, this antibody has been demonstrated to prevent chronic colitis and attenuate established colitis by down-regulation of both T-helper 1 and T-helper 17 activation (Takedatsu et al, 2008).

Flow Cytometry, ImmunoFluorescence, Neutralisation/Blocking

Research Use Only

Monoclonal

TAN2-2

Tnfsf15

tumor necrosis factor (ligand) superfamily, member 15

bM20K13.3 (tumor necrosis factor (ligand) superfamily, member 15); TL; Tl1; Tl1a; TNF ligand-related molecule 1; Tnlg1b; tumor necrosis factor ligand 1b; tumor necrosis factor ligand superfamily member 15; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor; VE; Vegi

Rat

IgG2a

Tumor necrosis factor ligand superfamily member 15

This reformatted rat antibody was made using the variable domain sequences of the original Rat IgG format, for improved compatibility with existing reagents, assays and techniques.

Mouse

-20°C,2°C to 8°C

12352203