Intracellular flow cytometry analysis of TLR3 in human PBMCs (lymphocytes) using 0.5microg/106 cells of anti-TLR3 (human), mAb (ABM15D5) (R-PE) (AG-20T-0301R). Green represents isotype control; red represents R-PE-conjugated anti-TLR3 (human), mAb
anti-TLR3 (human), mAb (ABM15D5) (R-PE)
AG-20T-0301R
Overview
- SupplierAdipoGen Life Sciences
- Product Nameanti-TLR3 (human), mAb (ABM15D5) (R-PE)
- Delivery Days Customer10
- Antibody SpecificityRecognizes human TLR3.
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDABM15D5
- Concentration0.2 mg/ml
- ConjugateRPE
- HostMouse
- IsotypeIgG1
- Scientific DescriptionMonoclonal Antibody. Recognizes human TLR3. Isotype: Mouse IgG1kappa. Clone: ABM15D5. Applications: FACS. Liquid. In PBS containing 0.05% sodium azide. TLR3 (Toll-like Receptor 3) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 consist of pathogen-binding ECDs (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 is a nucleotide-sensing TLR, activated by double-stranded RNA (dsRNA) which is associated with viral infection. Additional to dsRNA it binds also to synthetic ligands mimicking dsRNA (such as Poly I:C). It acts via the adapter TRIF/TICAM1 and induces the activation of IRF3, ultimately inducing the production of type I interferons (IFNs). It has been demonstrated extensively that TLR3 activation leads to cross-priming of CD8+ T cells via major histocompatibility complex I for the generation of cytotoxic T cell (CTL) responses. TLR3 displays a protective role in mouse models of atherosclerosis and against brain ischemia. - TLR3 (Toll-like Receptor 3) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 consist of pathogen-binding ECDs (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 is a nucleotide-sensing TLR, activated by double-stranded RNA (dsRNA) which is associated with viral infection. Additional to dsRNA it binds also to synthetic ligands mimicking dsRNA (such as Poly I:C). It acts via the adapter TRIF/TICAM1 and induces the activation of IRF3, ultimately inducing the production of type I interferons (IFNs). It has been demonstrated extensively that TLR3 activation leads to cross-priming of CD8+ T cells via major histocompatibility complex I for the generation of cytotoxic T cell (CTL) responses. TLR3 displays a protective role in mouse models of atherosclerosis and against brain ischemia.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203