anti-Tn antigen antibody [Tn 218]

Arigo Biolaboratories

anti-Tn antigen antibody [Tn 218]

23

ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry

Research Use Only

Monoclonal

Tn 218

0.2 mg/ml

Unconjugated

Mouse

IgM

Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approx. 90% of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells Fundamental chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primary breast carcinoma demonstrate it highly significant correlation with clinicopathological tumor stages, and hence its value as a reliable prognosticator.

-20°C

12352203