anti-TNF alpha antibody [B1E4] (HRP)

Arigo Biolaboratories

anti-TNF alpha antibody [B1E4] (HRP)

23

ELISA

Research Use Only

Monoclonal

B1E4

HRP

TNF

tumor necrosis factor

APC1 protein; DIF; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNF-alpha; TNFSF2; TNLG1F; tumor necrosis factor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha

Mouse

IgG1

Tumor Necrosis Factor alpha (TNF-alpha) is a multifunctional pro-inflammatory cytokine, mainly secreted by activated macrophages. TNF-alpha was named for its remarkable ability to cause hemorrhagic necrosis of tumors in mice. It is implicated with a variety of biological procedures including systemic inflammation, cell proliferation, apoptosis, lipid metabolism, and coagulation. The pleiotropic attribute of TNF-alpha regulation is associated with its ability to trigger multiple signalling pathways simultaneously. It is well documented that TNF-alpha functions through its receptors, TNFR1 (p55) and TNFR2 (p75). TNF-alpha not only contributes to the immune response to bacterial, fungal, viral and parasitic invasions, but also functions in tissue remodeling, autoimmune-diseases and the necrosis of specific tumors. TNF-alpha hyper-expression in response to some bacterial components such as LPS can cause life threatening septic shock. Recombinant TNF-alpha, in combination with chemotherapy, has been applied for treatment of soft sarcomas, melanomas and other irresectable tumors. Anti-TNF-alpha therapy has been used for treatment of rheumatoid arthritis.

Human

-20°C

12352203