Anti-TNFalpha [Di62]

Absolute Antibody

Anti-TNFalpha [Di62]

9

This antibody is specific for human TNFalpha.

This antibody binds to human TNFalpha with a high affinity (Kd = 0.4 nM) in ELISA analysis, and can block the interaction between TNFalpha and its receptor (Doring et al, 1994). In addition, this antibody inhibits human TNFalpha-induced cytotoxicity in several human and mouse cell lines, including murine L929 cells. A peptide derived from the CDR1 of the light chain of this antibody can also inhibit TNFalpha binding to L929 cells (Doring et al, 1994).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

Di62

TNF

tumor necrosis factor

APC1 protein; DIF; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNF-alpha; TNFSF2; TNLG1F; tumor necrosis factor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha

Rabbit

IgG

Tumor necrosis factor

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203