Anti-Transferrin Mouse mAb

PTM BIO

Anti-Transferrin Mouse mAb

5

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

WB, ICC/IF

Research Use Only

Monoclonal

JMMR-624

Unconjugated

Mouse

IgG

Serotransferrin

Transferrins are glycoproteins found in vertebrates which bind to and consequently mediate the transport of Iron (Fe) through blood plasma. They are produced in the liver and contain binding sites for two Fe3+ ions. Human transferrin is encoded by the TF gene and produced as a 76 kDa glycoprotein. Transferrin glycoproteins bind iron tightly, but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of total body iron, it forms the most vital iron pool with the highest rate of turnover (25 mg/24 hours). Transferrin has a molecular weight of around 80 kDa and contains two specific high-affinity Fe(III) binding sites. The affinity of transferrin for Fe(III) is extremely high, but decreases progressively with decreasing pH below neutrality. Transferrins are not limited to only binding to iron but also to different metal ions. These glycoproteins are located in various bodily fluids of vertebrates. Some invertebrates have proteins that act like transferrin found in the hemolymph.

Stable for 12 months from date of receipt/reconstitution.

Human

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203