Anti-TREM-1 [14F128]

Absolute Antibody

Anti-TREM-1 [14F128]

7

This antibody binds human, cynomolgus monkey and rhesus monkey TREM-1. TREM1 is a receptor that is expressed on monocytes, macrophages, neutrophils and dendritic cells. It plays important roles in innate and adaptive immunity by amplifying inflammatory re

The original IgG1 antibody binds human TREM-1 with an affinity of 2.4 nM as tested by suface plasmon resonance. The screening of original antibody for binding human TREM-1 was done using ELISA and flow cytometry. This antibody is capable of binding both human, cynomolgus monkey and rhesus monkey PBMCs. This antibody was able to reduce activation of BWZ/hTREM-1 reporter cell. This antibody was also able to block the ligand-induced TREM-1 activation in such BWZ/hTREM-1 reporter cell assay (US9000127).

Flow Cytometry, ELISA

ELISA; FC

Research Use Only

Monoclonal

14F128

TREM1

triggering receptor expressed on myeloid cells 1

CD354; TREM-1; triggering receptor expressed on monocytes 1; triggering receptor expressed on myeloid cells 1

Human

IgG1

Triggering receptor expressed on myeloid cells 1

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Human, Monkey, Primate

Human, cynomolgus monkey, rhesus monkey

The original antibody was generated by immunizing both wild type BALB/c mice and TREM-1 knock-out (KO) mice (C57BL/6 background) with either human TREM-1, cells expressing hTREM-1 (BWZ.36 cells), or a combination of both.

-20°C,2°C to 8°C

12352203