anti-TrkB antibody

Arigo Biolaboratories

anti-TrkB antibody

23

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.2 mg/ml

Unconjugated

NTRK2

neurotrophic receptor tyrosine kinase 2

BDNF/NT-3 growth factors receptor; BDNF-tropomyosine receptor kinase B; DEE58; EIEE58; GP145-TrkB; neurotrophic tyrosine kinase receptor type 2; OBHD; TRKB; trk-B; tropomyosin-related kinase B; tyrosine kinase receptor B

Rabbit

IgG

Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular weights of 140-145 kDa, 110 kDa and the unglycosylated form of 80 kDa. trkB contains 33.3% carbohydrate by weight representing modification on 10 of 12 N-glycosylation sites. The primary ligand for trkB is BDNF which induces the phosphorylation of the protein and subsequent binding of PLC-gamma via SH2 domains. TrkB may function to modulate neuronal responses to the neurotrophins acting through trkB such as BDNF.

Human

-20°C

12352203