Anti-TROP2 [hRS7 (Sacituzumab)]

Absolute Antibody

Anti-TROP2 [hRS7 (Sacituzumab)]

9

This antibody binds human TROP2 (EGP-1) protein, which functions in a variety of cell signaling pathways and was first elucidated as a transducer of an intracellular calcium signal. Trop-2 is involved in several cell signaling pathways, of which many are

The human IgG1 version of this antibody labelled with 131I-IMP-R4 was evaluated for the preclinical radioimmunotherapy (RAIT) of breast cancer. It was used for in vivo experiments in nude mice bearing subcutaneous MDA-MB-468 human breast cancer xenografts (PMID: 14999147). This antibody was used in the immunohistochemical staining of frozen sections of PC3 tumor xenografts. 111In-hRS7 and 89Zr-hRS7 labelled version of this antibody were used for the visualization of PC3 tumors in nude mice using immuno-PET and immuno-SPECT (PMID: 21865288). This antibody was also used in flow cytometric studies for detecting TROP-2 expressed on the surface of primary ovarian cancer cell lines. It was reported that primary ovarian carcinoma cell lines are highly sensitive to hRS7-mediated cytotoxicity in vitro (PMID: 21453957). The antibody drug conjugate hRS7-CL2A-SN-38 (ADC), was evaluated for its efficacy against human solid tumors and its tolerability was studies in mice and monkey. It was reported that the ADC provided specific anti-tumor effects against a variety of human solid tumor types and was well tolerated in monkeys (PMID: 21372224).

Flow Cytometry, ImmunoHistoChemistry, Other Application

Research Use Only

Monoclonal

hRS7 (Sacituzumab)

TACSTD2

tumor associated calcium signal transducer 2

40kD glycoprotein, identified by monoclonal antibody GA733; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; EGP1; EGP-1; epithelial glycoprotein-1; GA7331; GA733-1; gastrointestinal tumor-associated antigen GA7331; GP50; M1S1; membrane component, chromosome 1, surface marker 1; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; TROP2; trophoblast cell surface antigen 2; truncated TACSTD2; tumor-associated calcium signal transducer 2

Human

IgG1

Tumor-associated calcium signal transducer 2

This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203