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ProductsBack/Anti-Ubiquityl-Histone H2A (Lys119) Rabbit mAb

Anti-Ubiquityl-Histone H2A (Lys119) Rabbit mAb

PTM-1121
PTM BIO
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
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Overview

  • Supplier
    PTM BIO
  • Product Name
    Anti-Ubiquityl-Histone H2A (Lys119) Rabbit mAb
  • Delivery Days Customer
    5
  • Antibody Specificity
    Anti-Ubiquityl-Histone H2A (Lys119) Rabbit mAb detects histone H2A only when it is ubiquitinated at Lys119.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin
  • Applications Supplier
    WB, IHC-P, ICC/IF, IP, ChIP
  • Category Supplier
    Antibody
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    JRMR-353
  • Conjugate
    Unconjugated
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP04908
  • Protein Name
    Histone H2A type 1-B/E
  • Scientific Description
    Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Ubiquitination, a post-translational modification in which the ubiquitin is covalently attached to a substrate protein, occurs on histones H2A and H2B. Histone H2A is mono-ubiquitinated at Lys119 by the Polycomb Repressor Complex 1 (PRC1) and is critical for gene silencing, X chromosome inactivation, and cellular response to DNA damage. Histone H2A is also monoubiquitinated at Lys119 at sites of DNA damage.
  • Shelf life instruction
    Stable for 12 months from date of receipt/reconstitution.
  • Reactivity
    Human, Mouse, Rat
  • Reactivity Supplier
    Human, Mouse, Rat
  • Reactivity Supplier Note
    Protein A purified
  • Storage Instruction
    Store at -20°C. Avoid freeze/thaw cycles.
  • UNSPSC
    12352203

References

  • Wu Yanjie, et al. 'CBX8 together with SET facilitates ovarian carcinoma growth and metastasis by suppressing the transcription of SUSD2' MOLECULAR CANCER RESEARCH (2022)
    Read more
  • Zhao Ran, et al. 'CBX4 plays a bidirectional role in transcriptional regulation and lung adenocarcinoma progression' Cell Death & Disease (2024)
    Read more
  • Wu Yanjie, et al. 'CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and Metastasis by Suppressing the Transcription of SUSD2' MOLECULAR CANCER RESEARCH (2022)
    Read more