Anti-Urease alpha subunit [HpU-2]

Absolute Antibody

Anti-Urease alpha subunit [HpU-2]

9

HpU-2 binds specifically to H. pylori at the epitope with sequence SVELIDIGGNRRIFGFNALVDR - the sequence is part of a loop near to the C-terminus of the alpha subunit of urease (the beta subunit possesses the active site). HpU-18 competes with HpU-2 for b

HpU-2 results in ~82% inhibition (allosteric inhibition) of urease activity and the inhibitory activity is increased to 87% when HpU-2 is used in combination with HpU-19. HpU-2 has been shown be unsuccessful for use in IHC of formalin-fixed sections of H. pylori-infected human cells. HpU-2 can also be used in SPR and ELISA studies.

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

HpU-2

ureA

urease subunit alpha

HP_0073; HP_RS00370; HP0073; urease subunit alpha

Mouse

IgG2a

Urease subunit alpha

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

Bacteria

-20°C,2°C to 8°C

12352203