Anti-Valpha TCR [34]

Absolute Antibody

Anti-Valfa TCR [34]

7

This antibody binds to the T-cell receptor alpha chains.

The antibody binds specifically to the recombinant and native variable domain of the alpha chain which comprises the T-cell receptor (TCR). The TCR is a disulfide-linked heterodimeric protein expressed on the surface of T-cells in complex with CD3 and aeta-chain molecules. The receptor functions in the recognition of MHC molecule and the subsequent activation of T-cells. The monoclonal antibody 34 recognises Valpha regions of TCRs expressed in the 85.33 arthritogenic T-cell hybridoma and can be used to analyse TCR V gene expression and for immunotherapy in T cell mediated autoimmunity.

Flow Cytometry, Western Blot, ELISA

ELISA; FC; WB

Research Use Only

Monoclonal

34

Mouse

IgG2a

T-cell receptor alpha chain C region

This full-length, reformatted mouse antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.

Human

human

Purified recombinant soluble TCR from the T-cell hybridoma 85.33, corresponding to V alpha 11

-20°C,2°C to 8°C

12352203