Anti-V(beta)3 TCR [JOVI.1]

Absolute Antibody

Anti-V(beta)3 TCR [JOVI.1]

7

This antibody binds to human V-beta 3 chain of the T-cell receptor. In particular this antibody binds to the TRBC1 variant but not the TRBC2 variant.

This antibody can be used to detect the TCR beta chain in a majority (50-75%) of T-cell receptors by flow cytometry, immunofluorescence and can immunoprecipitate the TCR beta protein (variant 1). Recently it has been combined into a chimeric antigen antigen receptor therapy approach to selectively deplete a subset of T-cells in T-cell lymphomas or leukaemias, whilst leaving the non-reactive T-cell subset intact.

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoHistoChemistry

FACS; IHC; IF; IP

Research Use Only

Monoclonal

JOVI.1

Human

IgG1

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

Thymus, spleen and mesenteric lymph nodes isolated from a mouse transgenic for human Vb3 TcR.

-20°C,2°C to 8°C

12352203