Immunohistochemical staining of formalin-fixed and paraffin embedded human breast cancer tissue sections using anti-VISTA Rabbit Monoclonal Antibody (RM503) at 1:100 dilution.
Immunohistochemical staining of formalin-fixed and paraffin embedded human breast cancer tissue sections using anti-VISTA Rabbit Monoclonal Antibody (RM503) at 1:100 dilution.
anti-VISTA, Rabbit Monoclonal (RM503)
REV-31-1395-00
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetVSIR
Overview
- SupplierRevMAb Biosciences
- Product Nameanti-VISTA, Rabbit Monoclonal (RM503)
- Delivery Days Customer10
- Antibody SpecificityThis antibody reacts to human, mouse or rat VISTA.
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDRM503
- Gene ID64115
- Target nameVSIR
- Target descriptionV-set immunoregulatory receptor
- Target synonymsB7H5; B7-H5; C10orf54; DD1alpha; Death Domain1alpha; Dies1; GI24; PD-1H; PDCD1 homolog; platelet receptor GI24; PP2135; SISP1; sisp-1; stress-induced secreted protein-1; V-domain Ig suppressor of T cell activation; VISTA; V-set domain-containing immunoregulatory receptor; V-type immunoglobulin domain-containing suppressor of T-cell activation
- HostRabbit
- IsotypeIgG
- Protein IDQ9H7M9
- Protein NameV-type immunoglobulin domain-containing suppressor of T-cell activation
- Scientific DescriptionHuman VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells. - Recombinant Antibody. This antibody reacts to human, mouse or rat VISTA. Isotype: Rabbit IgG. Immunogen: A peptide corresponding to residues near the C-terminus of human VISTA. Application: IHC, WB. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203