Anti-ZIKV E domain [A9E]

Absolute Antibody

Anti-ZIKV E domain [A9E]

9

This antibody binds to ZIKV (probably its epitope spans part of EDIII and EDIII/EDI linker) and does not cross-react with DENV4, which was tested as a representative DENV serotype. Its epitope is distinct from the G9E anti-ZIKV antibody.

This antibody has very strong neutralizing properties against Asian and African lineages of ZIKV (Collins et al., 2019). Furthermore, this antibody was effective in preventing Zika infection when administered from one day before the infections in mice (Collins et al., 2019). Therefore, A9E is recommended in development of diagnostic assays which differentiate ZIKV from other flaviviruses (it does not crossreact with DENV) and in the development of therapeutics and vaccines against ZIKV.

Western Blot, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

A9E

Rabbit

IgG

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203