Anti-ZIKV E domain II [SMZAb2]

Absolute Antibody

Anti-ZIKV E domain II [SMZAb2]

9

SMZAb2 binds to domain II of the ZIKV E protein. This is distinct to the binding site of SMZAb5 and SMZAb1.

ELISA was used to confirm SMZAb2 binds to the ZIKV E domain, and neutralisation assays identified the IC50 of SMZAb2 as 189 ng/ml. Four macaques were injected with a cocktail of anti-Zika antibodies (SMZAb1, SMZAb2, SMZAb5) and then infected with ZIKV virus. The antibody cocktail appeared to confer sterilising immunity on the treated macaques and completely prevented viral replication, which was not seen with the control group (Magnani et al, 2017).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

SMZAb2

Mouse

IgG1

Envelope protein

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203