Anti-ZIKV E domain III [SMZAb5]

Absolute Antibody

Anti-ZIKV E domain III [SMZAb5]

9

SMZAb5 binds to domain III of the ZIKV E protein.

ELISA was used to confirm SMZAb5 binds to the ZIKV E domain, and neutralisation assays identified the IC50 of SMZAb5 as 3.8 ng/ml. Four macaques were injected with a cocktail of anti-Zika antibodies, including SMZAb5, and then infected with ZIKV virus. The antibody cocktail appeared to confer sterilising immunity on the treated macaques and completely prevented viral replication, which was not seen with the control group (Magnani et al, 2017).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

SMZAb5

Human

IgG1

Envelope protein

This reformatted human antibody was made using the variable domain sequences of the original Human IgG format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203