Overview
- SupplierGeneTex
- Product NameAKT (phospho Ser473) antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.43 mg/ml
- IsotypeIgG
- Scientific DescriptionThe serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
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- A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells. Hsieh CH et al., 2016, Drug Des Devel TherRead more
- Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A. Chao TT et al., 2015 Feb 10, OncotargetRead more
- Aluminum-Induced Synaptic Plasticity Impairment via PI3K-Akt-mTOR Signaling Pathway. Li H et al., 2020 Apr, Neurotox ResRead more
- Au2phen and Auoxo6, Two Dinuclear Oxo-Bridged Gold(III) Compounds, Induce Apoptotic Signaling in Human Ovarian A2780 Cancer Cells. Gorini G et al., 2021 Jul 23, BiomedicinesRead more
- Celastrol Inhibits Dopaminergic Neuronal Death of Parkinsons Disease through Activating Mitophagy. Lin MW et al., 2019 Dec 31, Antioxidants (Basel)Read more
- Chaperonin-Containing TCP-1 Promotes Cancer Chemoresistance and Metastasis through the AKT-GSK3beta-beta-Catenin and XIAP-Survivin Pathways. Chang YX et al., 2020 Dec 21, Cancers (Basel)Read more
- Characterization of TGF-beta by Induced Oxidative Stress in Human Trabecular Meshwork Cells. Chen HY et al., 2021 Jan 13, Antioxidants (Basel)Read more
- Constitutively active Akt1 cooperates with KRas(G12D) to accelerate in vivo pancreatic tumor onset and progression. Albury TM et al., 2015 Feb, NeoplasiaRead more
- CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer. Huang LC et al., 2018, Dis MarkersRead more