AKT (phospho Thr308) antibody

GeneTex

AKT (phospho Thr308) antibody

10

Flow Cytometry, Western Blot, ELISA

Research Use Only

Polyclonal

0.44 mg/ml

Rabbit

IgG

Phosphorylated

Akt (Protein Kinase B, PKB) is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of Akt has been seen in many types of cancer. Akt mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits Akt to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, Akt dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. Akt has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation.

Human, Mouse, Rat

2°C to 8°C,-20°C

12352203