Overview
- SupplierGeneTex
- Product NameAMPK alpha 2 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.96 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- AMP-activated kinase alpha2 deficiency protects mice from denervation-induced skeletal muscle atrophy. Guo Y et al., 2016 Jun 15, Arch Biochem BiophysRead more
- AMP-activated protein kinase is required for the anti-adipogenic effects of alpha-linolenic acid. Zhou X et al., 2015, Nutr Metab (Lond)Read more
- AMPKalpha2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction. Wang H et al., 2018 Jun, Free Radic Biol MedRead more
- Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells. Lee YZ et al., 2014 Aug 15, OncotargetRead more
- Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Lin YY et al., 2012 Feb 8, NatureRead more
- Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase alpha2. Gao J et al., 2020 Jan, Redox BiolRead more
- Muscle-specific deletion of Prkaa1 enhances skeletal muscle lipid accumulation in mice fed a high-fat diet. Wu W et al., 2018 May, J Physiol BiochemRead more
- Selenium-enriched exopolysaccharides improve skeletal muscle glucose uptake of diabetic KKAy mice via AMPK pathway. Zhou X et al., 2014 Jun, J Physiol BiochemRead more
- Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells. Hsu YF et al., 2012 Feb, Biochim Biophys ActaRead more