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GTX103487 IP Image
GTX103487 IP Image
GTX103487 IP Image

AMPK alpha 2 antibody

Research Use Only
GTX103487
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
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Overview

  • Supplier
    GeneTex
  • Product Name
    AMPK alpha 2 antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.96 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • AMP-activated kinase alpha2 deficiency protects mice from denervation-induced skeletal muscle atrophy. Guo Y et al., 2016 Jun 15, Arch Biochem Biophys
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  • AMP-activated protein kinase is required for the anti-adipogenic effects of alpha-linolenic acid. Zhou X et al., 2015, Nutr Metab (Lond)
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  • AMPKalpha2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction. Wang H et al., 2018 Jun, Free Radic Biol Med
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  • Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells. Lee YZ et al., 2014 Aug 15, Oncotarget
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  • Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Lin YY et al., 2012 Feb 8, Nature
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  • Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase alpha2. Gao J et al., 2020 Jan, Redox Biol
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  • Muscle-specific deletion of Prkaa1 enhances skeletal muscle lipid accumulation in mice fed a high-fat diet. Wu W et al., 2018 May, J Physiol Biochem
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  • Selenium-enriched exopolysaccharides improve skeletal muscle glucose uptake of diabetic KKAy mice via AMPK pathway. Zhou X et al., 2014 Jun, J Physiol Biochem
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  • Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells. Hsu YF et al., 2012 Feb, Biochim Biophys Acta
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