anti-APRIL (mouse), mAb (rec.) (blocking) (Apry-1-1)

Catalog number: AG-27B-0001-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 395.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-APRIL (mouse), mAb (rec.) (blocking) (Apry-1-1)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Subcategory: Other
Application: ELISA; ImmunoPrecipitation; Neutralisation/Blocking
Species: Mouse
Host: Mouse
Target: Tnfsf13
Target description: tumor necrosis factor (ligand) superfamily, member 13
Clonality: Monoclonal
Isotype: IgG2b Lambda
Properties: 
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Form supplied: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth and is involved in monocyte/macrophage-mediated immunological processes. Anti-APRIL (mouse) Monoclonal Antibody (recombinant) (Blocking) (APRY-1-1) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein. - Recombinant Antibody. Recognizes mouse APRIL. Does not recognize mouse BAFF. Species cross-reactivity: Mouse. Clone: Apry-1-1. Isotype: Mouse IgG2blambda. Applications: ELISA, FUNC (Blocking), IP. Host: Purified from HEK 293 cell culture supernatant. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth and is involved in monocyte/macrophage-mediated immunological processes. Anti-APRIL (mouse) Monoclonal Antibody (recombinant) (Blocking) (APRY-1-1) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.
Clone ID: Apry-1-1
Gene ID: 69583
Swiss prot ID: Q9D777
Safety information: 
MSDS: MSDS
Hazard information: Non-hazardous
Additional information: 
Synonyms: AG-27B-0001-C100; AdipoGen Life Sciences; 2310026N09Rik; a proliferation-inducing ligand; April; Tall2; Tnlg7b; Trdl1; tumor necrosis factor ligand 7b; tumor necrosis factor ligand superfamily member 13
Production of the plasma-cell survival factor APRIL peaks in myeloid precursor cells from human bone marrow: T. Matthes, et al.; Blood 118, 1838 (2011) Read more
Pathogenic role of a proliferation-inducing ligand (APRIL) in murine IgA nephropathy: Y.G. Kim, et al.; PLoS One 10, e0137044 (2015) Read more
The B cell-stimulatory cytokines BLyS and APRIL are elevated in human periodontitis and are required for B cell-dependent bone loss in experimental murine periodontitis: T. Abe, et al.; J. Immunol. 195, 1427 (2015) Read more
Splenic marginal zone granulocytes acquire an accentuated neutrophil B-cell helper phenotype in chronic lymphocytic leukemia: M. Gätjen, et al.; Cancer Res. 76, 5253 (2016) Read more