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Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
anti-Asc, pAb (AL177)
Catalog number:
AG-25B-0006-C100
Brand:
AdipoGen Life Sciences
Packing:
100 ug
Price:
€ 420.00
Expected delivery time:
7 days
Quantity:
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General
References
Product specifications for - anti-Asc, pAb (AL177)
Overview:
Product group:
Antibodies
Category:
Primary Antibodies
Application:
Functional Assay; ImmunoCytoChemistry; ImmunoHistoChemistry; ImmunoPrecipitation; Western Blot
Species:
Human, Mouse
Host:
Rabbit
Target:
PYCARD
Target description:
PYD and CARD domain containing
Clonality:
Polyclonal
Properties:
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352203
Concentration:
1 mg/ml
Form supplied:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
Asc promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. It is a component of the inflammasome, a protein complex which also includes NLRP3/NALP3, CARD8 and CASP1 and whose function is the activation of proinflammatory caspases. - Polyclonal Antibody. Recognizes human and mouse Asc. Source: Rabbit. Applications: FUNC, ICC, IHC, IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. Asc promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. It is a component of the inflammasome, a protein complex which also includes NLRP3/NALP3, CARD8 and CASP1 and whose function is the activation of proinflammatory caspases.
Gene ID:
29108
Swiss prot ID:
Q9ULZ3
Safety information:
MSDS:
MSDS
Hazard information:
Non-hazardous
Additional information:
Synonyms:
AG-25B-0006-C100; AdipoGen Life Sciences; apoptosis-associated speck-like protein containing a CARD; ASC; CARD5; caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; target of methylation-induced silencing 1; TMS; TMS1; TMS-1
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta: F. Martinon, et al.; Mol. Cell. 10, 417 (2002)
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NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder: L. Agostini, et al.; Immunity 20, 319 (2004)
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P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1beta in Mouse Macrophage: P. Pelegrin, et al.; J. Immunol. 180, 7147 (2008)
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Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF: L. Kolly, et al.; J. Immunol. 183, 4003 (2009)
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Activation of autophagy by inflammatory signals limits IL-1b production by targeting ubiquitinated inflammasomes for destruction: C.-S. Shi, et al.; Nat. Immunol. 13, 255 (2012)
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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice: M.T. Heneka, et al.; Nature 493, 674 (2013)
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Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation: J.K. Dowling, et al.; J. Biol. Chem. 289, 6429 (2014)
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Localization and functionality of the inflammasome in neutrophils: M. Bakele, et al.; J. Biol. Chem. 289, 5320 (2014)
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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation: B.S. Franklin, et al.; Nat. Immunol. 15, 727 (2014)
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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response: A. Baroja-Mazo, et al.; Nat. Immunol. 15, 738 (2014)
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