anti-ASC / TMS1 antibody

Arigo Biolaboratories

anti-ASC / TMS1 antibody

23

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Polyclonal

Unconjugated

PYCARD

PYD and CARD domain containing

apoptosis-associated speck-like protein containing a CARD; ASC; CARD5; caspase recruitment domain-containing protein 5; target of methylation-induced silencing 1; TMS; TMS1; TMS-1

Rabbit

IgG

ASC / TMS1 is an adaptor protein. It is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Human

-20°C

12352203