anti-ASC / TMS1 antibody

Catalog number: ARG63501_100ug
Brand: Arigo Biolaboratories
Packing: 100 ug
Price: € 621.00
Expected delivery time: 7 days
ARG63501 anti-ASC / TMS1 antibody IHC-P image
Immunohistochemistry: paraffin embe...
ARG63501 anti-ASC / TMS1 antibody WB image
Western Blot: HeLa lysate (35 µg pr...
ARG63501 anti-ASC / TMS1 antibody WB image
Western Blot: 1). Mock transfection...

Product specifications for - anti-ASC / TMS1 antibody

Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot, IHC-P
Application note: WB: Recommend incubate at RT for 1h. Approx. 22 kDa band observed in Hela and Human Kidney lysates (predicted MW of 22 kDa according to NP_037390.2). Recommended for use at 1-3 ug/ml. IHC-P: In paraffin embedded Human Liver shows staining of sinusoidal lining cells. Recommended concentration, 2-4 ug/ml. The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Species: Human
Host: Goat
Target: PYCARD
Target description: PYD and CARD domain containing
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 0,5 mg/ml
Form supplied: Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Storage instructions: For continuous use, store undiluted antibody at 2-8-¦C for up to a week. For long-term storage, aliquot and store at -20-¦C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Scientific information: 
Scientific info: This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm, however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene ID: 29108
Additional information: 
Synonyms: Inflammation research; ARG63501; Arigo Biolaboratories; PYCARD; TMS1; TMS-1; TMS; CARD5; ASC; target of methylation-induced silencing 1; caspase recruitment domain-containing protein 5; apoptosis-associated speck-like protein containing a CARD; PYD and CARD domain containing